Set-Up refers to the design of a specific Werewolf game. It is most commonly used to refer to whether a game is “open” or “closed” set-up. In open set-up, all roles, powers, and game mechanics are publicly revealed at the beginning of the game. In closed set-up, roles, powers, and some mechanics are kept secret. In a broad scope, set-up refers to everything from the execution method to which game mechanics are included, clear down to the individual scope of how individual roles or powers work.
See also List of Game Mechanics.